Episodic evolution in the stomach lysozymes of ruminants |
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| Authors: | Jacqueline Jollès Pierre Jolles Barbara H Bowman Ellen M Prager Caro-Beth Stewart Allan C Wilson |
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| Institution: | (1) Laboratory of Proteins, University of Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France;(2) Department of Biochemistry, University of California, 94720 Berkeley, California, USA;(3) Present address: Hormone Research Institute, University of California, 94143 San Francisco, CA, USA |
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| Abstract: | Summary By sequencing lysozymesc from deer and pig stomachs and comparing them to the known amino acid sequences of other lysozymesc, it was possible to examine the rate of sequence change during and after the period in which this enzyme acquired a new function.
Evolutionary tree analysis suggests that the rate went up while lysozyme was being recruited to function as a digestive enzyme
in the stomach of early ruminants. Later, presumably after lysozyme was well adapted for functioning in the new environment,
which contains acid, pepsin, and fermentation products, the rate of amino acid replacement became subnormal. |
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| Keywords: | Lysozyme sequences Positive selection Adaptive evolution Convergent evolution Molecular clocks Evolutionary trees Statistical testing Deer Pigs Digestion |
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