On the Mechanism of Action of <Emphasis Type="Italic">lac</Emphasis> Repressor |
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| Authors: | BEATRICE CHEN BENOIT DE CROMBRUGGHE WAYNE B ANDERSON MAX E GOTTESMAN IRA PASTAN ROBERT L PERLMAN |
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| Institution: | 1.Laboratory of Molecular Biology,National Cancer Institute, National Institutes of Health,Bethesda;2.Clinical Endocrinology Branch,National Institute of Arthritis and Metabolic Diseases, National Institutes of Health,Bethesda |
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| Abstract: | Chen et al. have proved conclusively that lac repressor and RNA polymerase bind independently to wild type lac DNA in vitro. To explain the lacp s mutation, which causes competitive binding between repressor and polymerase, they suggest that a new promoter site has been created near the lac operator. |
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