Fibroblast biology: Signals targeting the synovial fibroblast in arthritis |
| |
Authors: | YrjöT Konttinen Tian-Fang Li Mika Hukkanen Jian Ma Jing-Wen Xu Ismo Virtanen |
| |
Institution: | (1) Institute of Biomedicine, Helsinki, Finland;(2) Institute of Dentistry, University of Helsinki, Finland;(3) Surgical Hospital, Helsinki, Finland |
| |
Abstract: | Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals,
such as the following: ligands binding to cell surface receptors; lipid soluble, small molecular weight mediators (eg nitric
oxide NO], prostaglandins, carbon monoxide); extracellular matrix (ECM)-cell interactions; and direct cell-cell contacts,
including gap junctional intercellular communication. Joints are subjected to cyclic mechanical loading and shear forces.
Adherence and mechanical forces affect fibroblasts via the ECM (including the hyaluronan fluid phase matrix) and the pericellular
matrix (eg extracellular matrix metalloproteinase inducer EMMPRIN]) matrices, thus modulating fibroblast migration, adherence,
proliferation, programmed cell death (including anoikis), synthesis or degradation of ECM, and production of various cytokines
and other mediators 1]. Aggressive, transformed or transfected mesenchymal cells containing proto-oncogenes can act in the absence of lymphocytes,
but whether these cells represent regressed fibroblasts, chondrocytes or bone marrow stem cells is unclear. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|