Semi-continuous operation of the insect cell — Baculovirus system |
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Authors: | P R Piergiovanni K Dutt |
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Institution: | (1) Department of Chemical Engineering, Lafayette College, 18042 Easton, PA, USA |
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Abstract: | Summary The insect cell - baculovirus system is used to synthesize a variety of recombinant proteins, generally in a batch system. We have developed a semi-continuous system and studied its operation at three different residence times. The resulting data showed that beta-galactosidase can be produced for 50 to 150 hours longer than the batch system. |
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