Relationship between intravenous ethanol, alcohol-induced inhibition of pancreatic secretion and plasma concentration of immunoreactive pancreatic polypeptide, vasoactive intestinal peptide, and somatostatin in man |
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| Authors: | J L Staub H Sarles J A Chayvialle F Descos V Lassmann P Vague |
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| Affiliation: | 1. Unité de Recherches de Pathologie Digestive INSERM U 31, 46 boulevard de la Gaye, F-13009 Marseille, France;2. INSERM U 45, Hòpital Edouard Herriot, F-69000 Lyon, France;3. Diabetes Department, University Hòpital Michel Levy, F-13006 Marseille, France |
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| Abstract: | We have studied in seven men, consuming less than 50 g alcohol daily, the effect of intravenous (i.v.) ethanol on (a) hormonally (secretin + CCK PZ) submaximally stimulated pancreatic secretion and (b) blood levels of pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP) and somatostatin. After intravenous ethanol (600 mg/kg), pancreatic secretion decreased in all subjects and plasma levels of PP and VIP increased significantly. Moreover, there was a significant correlation between the mean inhibition of chymotrypsin output and the mean increase in PP plasma levels during the first 45 min following ethanol infusion. Therefore i.v. infusion of alcohol elicits release of PP and VIP and PP release could explain in part at least the alcohol-induced pancreatic inhibition observed in non-alcoholic men. |
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| Keywords: | alcohol pancreatic inhibition pancreatic polypeptide |
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