13年败血症的致病菌变迁和耐药谱研究

目的 阐明败血症多得耐药菌分布。方法 对我院１９８６年１月至１９９８年１２月１３年住院的１７０５例经血培养阳性证实的败血症进行致病菌分布与年代比较、耐药性分析。结果 发现以金葡萄为主的Ｇ＾＋菌占４９．５５％、大肠杆菌为主的Ｇ菌占４９．０６％、Ｌ型菌０．９３％、真菌０．４４％，复数菌４．５１％。葡萄球菌７２５（４０．００％）占首位，有上升趋势；不动杆菌、克雷伯菌、嗜麦芽黄单胞菌等崛起并增多；大肠杆菌

CHANGE AND DRUG-TOLERNACE SPECTRA OF SEPTICEMIC PATHOGENIC BACIERIA IN THIRTEEN YEARS

Objective:To illuminate distribution of drug- resistance- m ultiple bacteria of septicem ia. Methods:This retrospective study included170 5 inpatients with septicemia proved by blood culture be- tween January1986 and December1998:comparison of distribution of pathogenic bacteria in different ages and analysis of drug- tolerance.Results:Gram- positive bacteria,mainly Staphylococcus aureus,accounted for49.5 5 percent;gram- negative bacteria,mainly Escherichia coli49.0 6 percent;L bacteria,0 .93percent; fugus,0 .44 percent;multiple- bacteria,4.5 1percent.Staphylococcus aureus,72 5 strains(4 0 .0 0 percent) , were m ost and adding up.Acinetobacter,klebsiella and Xanthomonas maltohilia appeared and increased, while Escherichia coli and Pseudom om as aeruginosa decreased,MRSA and MRSE acconnted for75 per- cent.In gram- negative bacteria included Escherichia coli,there were38to6 6 percent strains tolerating cef- operazone,ceftriaxone and cefatazxidime.Conclusion First nine drug- resistance- multiple bacteria of sep- ticem ia are Staphylococcus aureus,Escherichia coli,Staphylococcus epiderm idis,pseudom onas aeruginosa, Acinetobacter,Xanthomonas maltophilia,Klebsiella pneumoniae,Enterobacter aerogenes and Enterococ- cus respectively.