Histology far away from Flatland: 3D roller-coasting into grade-dependent angiogenetic patterns in oligodendrogliomas |
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Authors: | Cassoni P Gaetano L Senetta R Bussolati B Molinaro L Bussolati G |
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Institution: | Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy. |
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Abstract: | Angiogenesis plays a key role in tumour progression, and undergoes structural changes associated to tumour biology itself. Although vessel density can be easily evaluated in brain tumours using a traditional immuno-histochemical approach, other parameters of conceptual/biological interest, such as the complex patterns of vascular growth, cannot be fully understood using a traditional bi-dimensional evaluation. We use here surgical specimens derived from oligodendrogliomas as a model for a novel elucidative 3D reconstruction of the grade-dependent vascular arborisation in brain tumours. |
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Keywords: | 3D oligodendroglioma angiogenesis |
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