Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle |
| |
Authors: | A Katz B L Nyomba C Bogardus |
| |
Institution: | Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, Phoenix, AZ 85016. |
| |
Abstract: | 1. The effects of physiologic concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact human skeletal muscle have been investigated. 2. Insulin increased glucose 1,6-P2 from a basal value of 70 +/- 6 to 135 +/- 12 mumol/kg dry wt (P less than 0.001). 3. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, Pi, citrate) or its substrate glucose 6-P. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|