Platelet membrane molecular organization: relationship with membrane bound calcium |
| |
| Authors: | F Rendu J Viret D Daveloose S Levy-Toledano F Leterrier |
| |
| Institution: | 1. Division de Biophysique du Centre de Recherches du Service de Santé des Armées, 1 Bis, rue du Lieutenant Raoul Batany F. 92141 Clamart, France;1. Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal;2. Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383, Wroclaw, Poland |
| |
| Abstract: | The fatty acid spin label 5 nitroxide stearate has been used to determine the membrane organization changes induced by platelet aggregation. A decrease in order is observed with thrombin, even in the presence of EDTA, when aggregation is inhibited. Conversely, after aggregation by the calcium ionophore A23187 the rigidity of the phospholipids is not modified. These effects are discussed in relation to the release of membrane bound calcium induced by thrombin. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
