首页 | 本学科首页   官方微博 | 高级检索  
     


GenePath: a system for automated construction of genetic networks from mutant data
Authors:Zupan Blaz  Demsar Janez  Bratko Ivan  Juvan Peter  Halter John A  Kuspa Adam  Shaulsky Gad
Affiliation:University of Ljubljana, Faculty of Computer and Information Science Jozef Stefan Institute, Ljubljana, Slovenia.
Abstract:MOTIVATION: Genetic networks are often used in the analysis of biological phenomena. In classical genetics, they are constructed manually from experimental data on mutants. The field lacks formalism to guide such analysis, and accounting for all the data becomes complicated when large amounts of data are considered. RESULTS: We have developed GenePath, an intelligent assistant that automates the analysis of genetic data. GenePath employs expert-defined patterns to uncover gene relations from the data, and uses these relations as constraints in the search for a plausible genetic network. GenePath formalizes genetic data analysis, facilitates the consideration of all the available data in a consistent manner, and the examination of the large number of possible consequences of planned experiments. It also provides an explanation mechanism that traces every finding to the pertinent data. AVAILABILITY: GenePath can be accessed at http://genepath.org. SUPPLEMENTARY INFORMATION: Supplementary material is available at http://genepath.org/bi-.supp.
Keywords:
本文献已被 PubMed Oxford 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号