| 线粒体铁蛋白与铁相关的神经退行性疾病 |
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| 引用本文： | 赵亚硕,石振华,常彦忠. 线粒体铁蛋白与铁相关的神经退行性疾病[J]. 生物物理学报, 2012, 0(4): 317-323 |
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| 作者姓名： | 赵亚硕 石振华 常彦忠 |
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| 作者单位： | 河北师范大学生命科学学院;河北师范大学分析测试中心 |
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| 基金项目： | 国家自然科学基金项目(10979025);河北省杰出青年基金项目(C2010002032)~~ |
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| 摘 要： | 在哺乳动物体内,线粒体铁蛋白(mitochondrial ferritin,MtFt)是一个无内含子的基因编码的蛋白,与胞质中的H-ferritin具有较高的同源性,也具有亚铁氧化酶的活性,特异性地在线粒体中表达。近年来的研究发现,过表达MtFt可以使线粒体免受由铁引起的氧化损伤。本文主要介绍MtFt在结构功能上的特点,及其在与铁相关的一些神经退行性疾病中的保护作用。
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| 关 键 词： | 线粒体铁蛋白 氧化应激 神经退行性疾病 |
Mitochondria Ferritin and Iron-Related Neurodegenerative Diseases |
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| ZHAO Yashuo,SHI Zhenhua,CHANG Yanzhong. Mitochondria Ferritin and Iron-Related Neurodegenerative Diseases[J]. Acta Biophysica Sinica, 2012, 0(4): 317-323 |
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| Authors: | ZHAO Yashuo SHI Zhenhua CHANG Yanzhong |
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| Affiliation: | 1,2 1.College of Life Science,Hebei Normal University,Shijiazhuang 050024,China; 2.Instrumental Analysis Centers,Hebei Normal University,Shijiazhuang 050024,China |
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| Abstract: | In the mammalia,mitochondria ferritin(MtFt) was encoded by intronless genes,it has high homology with cytoplasmic of H-ferritin and has ferrousoxidase activity.The MtFt is specifically targeted to mitochondria.Recent studies found that MtFt overexpression had a role in protecting mitochondria from iron-induced damage.This paper mainly introduces the structure and function of MtFt and the defense of MtFt in some of the iron-related neurodegenerative diseases. |
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| Keywords: | Mitochondria ferritin Oxidative stress Neurodegenerative diseases |
| 本文献已被 CNKI 等数据库收录！ |
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