Phytochemistry and antimycobacterial activity of Chlorophytum inornatum |
| |
Authors: | O'Donnell Gemma Bucar Franz Gibbons Simon |
| |
Affiliation: | Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. |
| |
Abstract: | In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as 7-(1'-hydroxyethyl)-2-(2'-hydroxyethyl)-3,4-dihydrobenzopyran (2) was characterised by extensive 1- and 2D NMR spectroscopy. The antimycobacterial activity of this plant was mainly due to the homoisoflavonoid which exhibited minimum inhibitory values ranging from 16-256 microg/ml against four strains of fast-growing mycobacteria. |
| |
Keywords: | Chlorophytum inornatum Homoisoflavanone Liliaceae Mycobacterium Antibacterial Mycobacteria |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|