Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic versus calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability of human blood lymphocytes |
| |
Authors: | Glavas-Obrovac Ljubica Suver Mirjana Hikishima Sadao Yokomatsu Tsutomu Bzowska Agnieszka |
| |
Affiliation: | Clinical Hospital Osijek and School of Medicine, University of J. J. Strossmayer in Osijek, Osijek, Croatia. |
| |
Abstract: | Several cyclic and acyclic 6-keto purine nucleotides with difluoromethylenephosphonic acid as phosphate mimic are proved to be potent inhibitors of mammalian purine nucleoside phosphorylase (PNP). Antiproliferative activity of these analogues on the growth of human blood lymphocytes was tested by MTT assay. Compared to inhibitory effects on the growth of human blood T-lymphocytes isolated from healthy donors, all analogues significantly slow down proliferation of T-lymphocytes isolated from patients with autoimmune thyroid disease--Hashimoto's thyroiditis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |