Effects of α-amanitin on the stimulation of prostatic ribonucleic acid polymerase by prostatic steroid–protein receptor complexes (Short Communication) |
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| Authors: | P. Davies and K. Griffiths |
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| Affiliation: | Tenovus Institute for Cancer Research, Welsh National School of Medicine, Heath Park, Cardiff CF4 4XX, U.K. |
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| Abstract: | Stimulation of prostatic RNA polymerase in vitro by prostatic 17beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone)-receptor complexes has been previously reported. By use of the selective inhibitor, alpha-amanitin, we have shown that both nucleolar and extranucleolar RNA polymerase activities may be stimulated, but stimulation is abolished at high ionic strength. |
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