Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist |
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Authors: | Natalja Genina Heikki Räikkönen Jyrki Heinämäki Osmo Antikainen Simo Siiriä Peep Veski Jouko Yliruusi |
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Institution: | (1) Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland;(2) Department of Pharmacy, University of Tartu, Nooruse 1, 50411 Tartu, Estonia |
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Abstract: | The goal of the present study was to design a new technique to modify particle surface properties and, through that, to improve
flowability of poorly flowing drug thiamine hydrochloride and pharmaceutical sugar lactose monohydrate of two different grades.
The powdered particles were supplied by a vibratory feeder and exposed to an instantaneous effect of water mist generated
from an ultrasound nebulizer. The processed and original powders were evaluated with respect to morphology (scanning electron
microscopy, atomic force microscopy, and spatial filtering technique), flow, and solid state properties. It was found that
rapid exposition of pharmaceutical materials by water mist resulted in the improvement of powder technical properties. The
evident changes in flowability of coarser lactose were obviously due to smoothing of particle surface and decreasing in the
level of fines with very slight increment in particle size. The changes in thiamine powder flow were mainly due to narrowing
in particle size distribution where the tendency for better flow of finer lactose was related to surface and size modifications.
The aqueous mist application did not cause any alteration of the crystal structures of the studied materials. The proposed
water mist treatment technique appears to be a robust, rapid, and promising tool for the improvement of the technological
properties of pharmaceutical powders. |
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Keywords: | flow properties lactose monohydrate surface properties thiamine hydrochloride ultrasonic water mist |
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