Enzyme inhibition activities of the extracts from rhizomes of Gloriosa superba Linn (Colchicaceae) |
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Authors: | Khan Haroon Khan Murad Ali Hussan Iqbal |
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Institution: | Department of Pharmacy, University of Peshawar, N. W.F.P, Pakistan. harronkhan3@yahoo.com |
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Abstract: | An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was screened for enzyme inhibition activities. The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease. An outstanding inhibition on lipoxygenase was observed. The highest enzyme inhibition potency was expressed by the chloroform fraction (90%) among the tested fractions on lipoxygenase. Overall 67-90% inhibition was found for lipoxygenase, 46-69% for acetylcholinesterase and 10-33% for butyrylcholinesterase, while urease was not inhibited. |
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