Schistosoma mansoni: stimulatory effect of rat skin lipid fractions on cercarial penetration behavior |
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| Authors: | F G Austin M A Stirewalt R E Danziger |
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| Affiliation: | 1. Center of Excellence for Advanced Materials, Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0416, United States;2. Department of Mechanical Engineering, University of Massachusetts, Lowell, 1 University Ave, Lowell, MA 01854, United States;1. Bern Univ. of Applied Sciences - HAFL, Länggasse 85, CH-8052 Zollikofen, Switzerland;2. Interdisciplinary Centre for Mountain Research, University of Lausanne, Site de Sion, Case Postale 4176, CH-1950 Sion 4 , Switzerland;3. ARCOWA SA, Postbox 1009, Rue de Collège 19, CH-1260 Nyon, Switzerland;4. Institute for Environmental Sciences, University of Geneva, 66 Bvd Carl Vogt, CH-1205 Geneva, CH, Switzerland;5. Department of Earth Sciences, University of Geneva, rue des Maraîchers 13, CH-1205 Geneva, Switzerland;1. Post Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India;2. Department of Chemistry, AVS College of Arts and Science, Ramalingapuram, Salem 636 106, Tamil Nadu, India |
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| Abstract: | Rat tail surface lipids were separated on thin-layer chromatography plates into seven neutral lipid fractions. Each fraction was tested as a penetration stimulus in the presence of Schistosoma mansoni cercariae on a tanned animal membrane which, untreated, did not attract or stimulate the parasites. The most polar fraction (A) was most stimulatory, the next fraction (B) was moderately stimulatory, and the remaining five fractions (CG) were only slightly or nonstimulatory. Fraction A, about 2% of the total, was believed to be a fatty acid polyol ester and fraction B, approximately 2% of the total, was free fatty acid. The remaining five fractions (CG) contained cholesterol, sterol esters and fatty acid esters less polar than those of fraction A. |
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