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P-14CERVICAL DYSPLASIA AND RISK FACTORS IN NORTHERN IRELAND SLE PATIENTS |
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| Authors: | M T McHenry K Cuschieri C Moore H A Cubie R Clarke N Anderson & A L Bell |
| Institution: | Queen's Lupus Research Group, Musgrave Park Hospital, Belfast, UK;, New Royal Infirmary Hospital, Edinburgh, UK;, Craigavon Hospital Group Trust, Craigavon, UK;and Belfast Link Laboratories, Belfast, UK |
| Abstract: | Introduction: An increased risk of cervical dysplasia has previously been reported in lupus. The role of traditional related risk factors are unclear. Persistent infection with certain genotypes of Human Papilloma Virus termed high risk (HR-HPV) is considered a prerequisite for the development of cervical cancer. Methods: A total of 141 SLE patients fulfilling the ACR criteria for lupus were enrolled into the study. They were compared to 138 control patients who were due to attend for a routine cervical smear. Each patient completed a cervical cancer risk factor questionnaire. A cervical smear was taken and residual material used to test for the presence of HR-HPV using a hybridisation microplate assay. Positive samples were then genotyped. Results: |
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