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Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement |
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| Authors: | Zhang Na Lin Chin Huang Xuanwei Kolbanovskiy Aleksandr Hingerty Brian E Amin Shantu Broyde Suse Geacintov Nicholas E Patel Dinshaw J |
| Affiliation: | Program in Cellular Biochemistry and Biophysics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. |
| Abstract: | |
| Keywords: | conformational switch cytosine methylation p53 mutation hot spot DNA adduct benzo[a]pyrene B[a]PDE |
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