Triacylglycerol lipases of the yeast |
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Authors: | Karlheinz Grillitsch G??nther Daum |
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Institution: | 1. ACIB GmbH-Austrian Centre of Industrial Biotechnology Institute of Biochemistry, Graz University of Technology, Graz, 8010, Austria
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Abstract: | All eukaryotes including the yeast contain a lipid storage compartment which is named lipid particle, lipid droplet or oil
body. Lipids accumulating in this subcellular fraction serve as a depot of energy and building blocks for membrane lipid synthesis.
In the yeast, the major storage lipids are triacylglycerols (TGs) and steryl esters (SEs). An important step in the life cycle
of these non-polar lipids is their mobilization from their site of storage and channeling of their degradation components
to the appropriate metabolic pathways. A key step in this mobilization process is hydrolysis of TG and SE which is accomplished
by lipases and hydrolases. In this review, we describe our recent knowledge of TG lipases from the yeast based on biochemical,
molecular biological and cell biological information. We report about recent findings addressing the versatile role of TG
lipases in lipid metabolism, and discuss non-polar lipid homeostasis and its newly discovered links to various cell biological
processes in the yeast. |
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Keywords: | triacylglycerol lipase fatty acid acyltransferase lipid droplet/particles yeast |
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