Optimized homology searches of the gene and protein sequence data banks |
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| Authors: | Charles B. Lawrence Daniel A. Goldman Robert T. Hood |
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| Affiliation: | (1) Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, 77030 Houston, TX, U.S.A.;(2) Department of Computer Science, Rice University, 77251-1892 Houston, TX, U.S.A. |
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| Abstract: | A strategy is presented for searching the gene and protein sequence data banks which combines the use of two previously described algorthms. The implementation of this strategy is thoroughly evaluated with respect to sensitivity, specificity and speed. The establishment of standard benchmarks for comparing programs that rearch the sequence data banks for homology is proposed. |
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