No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity |
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| Authors: | Yu-Lin Ko Shih-Ann Chen Tang K Tang Jiunn-Lee Lin Chern-En Chiang Jin-Jer Chen Ming-Sheng Teng Mau-Song Chang Wen-Pin Lien Cheng-Wen Wu |
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| Institution: | (1) Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China;(2) Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Repubic of China;(3) Division of Cardiology, Department of Medicine, Veterans General Hospital-Taipei, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China |
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| Abstract: | Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individuals were diagnosed to be affected, according to electrocardiographic criteria. Two genomic DNA probes (c-Ha-ras-3 -HVR and insulin-5-HVR) and one tetranucleotide repeat polymorphism (THZ) derived from chromosome 11p15.5 loci and previously demonstrated to be closely linked to LQT were used as probes to analyze this family. A lod score of less than -2 was noted for all three polymorphisms. Our data show that there was no evidence of linkage between these three loci and the gene for LQT in this studied family. We believe that this result provides additional evidence for genetic heterogeneity of LQT. |
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