Ia-positive T lymphocytes are the producer cells of interferon gamma |
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Authors: | I Schober R Braun H Reiser K Munk M Leroux H Kirchner |
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Institution: | Institute of Virus Research, German Cancer Research Center, 6900-Heidelberg, FRG |
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Abstract: | The production of γ-interferon (IFNγ) in human peripheral blood T lymphocytes was induced by stimulation with PHA. For identification of the producer cell of IFNγ, double fluorescence studies were undertaken and titers of interferon were determined in preparatively separated T-cell subpopulations reactive with one of the monoclonal antibodies OKT3, OKT4, OKT8, and OKIa1. Production of IFNγ was found in OKT3+, OKT4+, and OKT8+ cells. However, IFNγ production occurred only in T cells also reactive with the monoclonal antibody OKIa1. Addition of macrophages had no substantial effect on interferon titers in these subpopulations. It is suggested that the T cell subset producing IFNγ is characterized by its reactivity with the monoclonal antibodies OKT3, OKT4 or OKT8, and OKIa1. |
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Keywords: | To whom offprint requests should be sent |
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