Corticosterone decreases the efficacy of adrenaline to affect passive avoidance retention of adrenalectomized rats |
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Authors: | J Borrell E R de Kloet B Bohus |
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Affiliation: | 1. Rudolf Magnus Institute for Pharmacology University of Utrecht, Vondellan 6. 3521 GD Ultecht, The Netherlands;2. Department of Animal Physiology, University of Groningen, P.O. Box 14. 9750 AA Haren, The Netherlands |
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Abstract: | Short-term (48h) adrenalectomy (ADX) resulted in a deficit in the retention of a passive avoidance response. An inverted U-shaped dose-response relationship was found following immediate post-learning administration of adrenaline (A). A in a dose range of 0.005 - 5 micrograms/kg s.c. facilitated later retention. While corticosterone (CS) replacement alone had no effect, pretreatment with CS (300 micrograms/kg) was followed by a shift in the dose-response curve of A in ADX rats. Ten thousand times higher doses of A were required to improve retention behavior. Administration of the potent synthetic glucocorticoid dexamethasone failed to affect the responsiveness to A. It is concluded that corticosterone decreases the efficacy by which adrenaline affects later retention behavior of ADX rats. The specificity of corticosterone in this interaction suggests the involvement of the corticosterone receptor system which has its predominant localization in hippocampal neurons. |
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Keywords: | Send all correspondence to B. Bohus at the Department of Animal Physiology University of Groningen P.O. Box 14 9750 AA Haren The Netherlands |
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