RNA-directed repair of DNA double-strand breaks |
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| Affiliation: | 1. Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China;4. Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China;1. Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH;2. Department of Urology, Cancer Center, Sun Yat-Sen University, Guangzhou, People''s Republic of China;3. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH;4. Department of Urology, Cleveland VA/Case Medical Center, Cleveland, OH;1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States;2. Department of Molecular and Cellular Physiology and Structural Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Palo Alto, CA 94305, United States;1. Department of Cutaneous Oncology, Sarcoma, H. Lee Moffitt Cancer Center, Tampa, FL, United States;2. Department of Diagnostic Imaging, Sarcoma, H. Lee Moffitt Cancer Center, Tampa, FL, United States;3. Department of Anatomic Pathology, Sarcoma, H. Lee Moffitt Cancer Center, Tampa, FL, United States;1. Department of Medical Oncology, Giovanni Borea Hospital, Sanremo, Italy;2. Department of Radiotherapy, Ospedali Riuniti, Ancona, Italy |
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| Abstract: | DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, which if unrepaired or repaired incorrectly can cause cell death or genome instability that may lead to cancer. To counteract these adverse consequences, eukaryotes have evolved a highly orchestrated mechanism to repair DSBs, namely DNA-damage-response (DDR). DDR, as defined specifically in relation to DSBs, consists of multi-layered regulatory modes including DNA damage sensors, transducers and effectors, through which DSBs are sensed and then repaired via DNAprotein interactions. Unexpectedly, recent studies have revealed a direct role of RNA in the repair of DSBs, including DSB-induced small RNA (diRNA)-directed and RNA-templated DNA repair. Here, we summarize the recent discoveries of RNA-mediated regulation of DSB repair and discuss the potential impact of these novel RNA components of the DSB repair pathway on genomic stability and plasticity. |
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| Keywords: | DNA damage response DNA repair RNA MicroRNA diRNA Double-strand break DSBs" },{" #name" :" keyword" ," $" :{" id" :" kw0040" }," $$" :[{" #name" :" text" ," _" :" DNA double-strand breaks DDR" },{" #name" :" keyword" ," $" :{" id" :" kw0050" }," $$" :[{" #name" :" text" ," _" :" DNA-damage-response as defined specifically in relation to DSBs diRNA" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" DSB-induced small RNA NHEJ" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" non-homologous end-joining HR" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" homologous recombination Ago2" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" Argonaute2 RISC" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" RNA-induced silencing complex |
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