BRCA1: Beyond double-strand break repair |
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| Affiliation: | 1. Cancer Biology Division, KIIT School of Biotechnology, KIIT University, Campus-11, Patia, Bhubaneswar, Orissa 751024, India;2. Institute of Life Sciences, Nalco Square, Bhubaneswar, Orissa 751023, India;3. Department of Biotechnology, Visva Bharati University, Santiniketan, West Bengal, India;1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Siteman Cancer Center, St. Louis, MO, United States;2. NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, United States;3. Division of Gynecologic Oncology (FB), Anatomic Pathology (NCR), Obstetrics and Gynecology (PG), Ohio State University, Columbus, OH, United States;4. Gynecologic Oncology, Stephenson Oklahoma Cancer Center, Oklahoma City, OK, United States;5. Gynecologic Oncology, Women and Infants Hospital, Providence, RI, United States;6. Gynecologic Oncology, University of Colorado Cancer Center, Aurora, CO, United States;7. Gynecologic Oncology, University Hospital Case Medical Center, Cleveland, OH, United States;8. Gynecologic Oncology, University of Minnesota Medical School, Minneapolis, MN, United States;9. Gynecologic Oncology, Stony Brook University Hospital, Stony Brook, NY, United States |
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| Abstract: | Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications. |
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