XPC: Going where no DNA damage sensor has gone before |
| |
| Affiliation: | 1. Department of Otorhinolaryngology, The First AffiliatedHospital of Xinxiang Medical University, Weihui, China;2. Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China;3. Oncology Department, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China;4. Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Jining Medical University, Jining, China;1. Inserm U1035, Bordeaux, France;2. Université de Bordeaux, Bordeaux, France;3. Centre Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, Bordeaux, France;4. Centre de Référence pour les Maladies Rares de la Peau, CHU de Bordeaux, France;5. Université de Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM), Bordeaux, France;6. Département de Dermatologie and Dermatologie Pédiatrique, CHU de Bordeaux, France |
| |
| Abstract: | XPC has long been considered instrumental in DNA damage recognition during global genome nucleotide excision repair (GG-NER). While this recognition is crucial for organismal health and survival, as XPC’s recognition of lesions stimulates global genomic repair, more recent lines of research have uncovered many new non-canonical pathways in which XPC plays a role, such as base excision repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and cellular viability. Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably. Indeed, our understanding appears to barely scratch the surface of the incredible potential influence of XPC on maintaining proper cellular function. Here, we first review the canonical role of XPC in lesion recognition and then explore the new world of XPC function. |
| |
| Keywords: | DNA repair Nucleotide excision repair XPC Rad4 BER GG-NER |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
