Chromatin plasticity in response to DNA damage: The shape of things to come |
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| Affiliation: | 1. Epigenome Integrity Group, UMR 7216 CNRS/Paris Diderot University, 35 rue Helene Brion, 75013 Paris, France;2. Chromatin Dynamics Group, UMR 3664 CNRS/Institut Curie Research Center, 26 rue d’Ulm 75005 Paris, France;1. Institute of Cancer Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK;2. The Christie NHS Foundation Trust, Manchester, UK;1. Department of Ultrasound, The 302 Hospital of PLA, Beijing, China;2. Department of Ultrasound, The First Hospital Affiliated with Shanxi Medical University, Taiyuan, China;3. Department of Pathology, The 302 Hospital of PLA, Beijing, China;1. Dipartimento di Matematica, Università di Trento, 38123 Povo (TN), Italy;2. Mathematisches Institut, Universität Bern, Sidlerstrasse 5, 3012 Bern, Switzerland;1. Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital Solna, Sweden;2. Department of Obstetrics and Gynecology, Karolinska University Hospital Solna, Sweden;3. Department of Cardiothoracic Surgery, Karolinska University Hospital Solna, Sweden;4. Department of Cardiology, Karolinska University Hospital Solna, Sweden;5. Section of Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden |
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| Abstract: | DNA damage poses a major threat to cell function and viability by compromising both genome and epigenome integrity. The DNA damage response indeed operates in the context of chromatin and relies on dynamic changes in chromatin organization. Here, we review the molecular bases of chromatin alterations in response to DNA damage, focusing on core histone mobilization in mammalian cells. Building on our current view of nucleosome dynamics in response to DNA damage, we highlight open challenges and avenues for future development. In particular, we discuss the different levels of regulation of chromatin plasticity during the DNA damage response and their potential impact on cell function and epigenome maintenance. |
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| Keywords: | Chromatin dynamics Chromatin remodelers DNA damage repair Epigenome maintenance Histone chaperones Histone variants |
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