Occurrence of leu+ revertants under starvation cultures in Escherichia coli is growth-dependent |
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| Authors: | Jianling Jin Peiji Gao Yumin Mao |
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| Institution: | (1) State key laboratory of microbial technology, Shandong University, 27 Shanda South Road, Jinan, 250100, P.RChina;(2) State key laboratory of microbial technology, Shandong University, 27 Shanda South Road, Jinan, 250100, P.R.China;(3) State key laboratory of genetic engineering, Fudan University, 220 Handan Road, Shanghai, 200433, P.R.China |
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| Abstract: | Background Many investigations have reported that advantageous mutations occurred more frequently under selective conditions than those under non-selective conditions. This phenomenon is referred to as adaptive mutation. Their characteristics are that adaptive mutations are directed and growth-independent. The idea of directed adaptive mutation had been objected by some reports, however, the idea of growth-independent adaptive mutation has been held till today. |
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