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Nucleolar localization of an isoform of the IGF-I precursor |
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| Authors: | Daniel?SW?Tan Alexandra?Cook |
| Institution: | (1) Department of Endocrinology, St Bartholomew's Hospital, Queen Mary, University of London, EC1A 7BE London, United Kingdom |
| Abstract: | BackgroundAlternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the signal and mature IGF-I domains. |
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