(1) Department of Microbiology, University of Washington, School of Medicine, Seattle, WA 98195, USA;(2) Department of Structural Biology, Stanford University, School of Medicine, Stanford, CA 94305, USA
Abstract:
Background
We thoroughly analyse the results of 40 blind predictions for which an experimental answer was made available at the fourth meeting on the critical assessment of protein structure methods (CASP4). Using our comparative modelling and fold recognition methodologies, we made 29 predictions for targets that had sequence identities ranging from 50% to 10% to the nearest related protein with known structure. Using our ab initio methodologies, we made eleven predictions for targets that had no detectable sequence relationships.