SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines |
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| Authors: | Ada Ching Katherine S Caldwell Mark Jung Maurine Dolan Oscar S Smith Scott Tingey Michele Morgante Antoni J Rafalski |
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| Institution: | (1) DuPont Crop Genetics, Delaware Technology Park, Suite 200, P.O. Box 6104, Newark, Delaware 19714, USA;(2) Present address: Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, Scotland;(3) Pioneer Hi-Bred International, P.O. Box 1004, Johnston, IA 50131-1004, USA |
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| Abstract: | Background Recent studies of ancestral maize populations indicate that linkage disequilibrium tends to dissipate rapidly, sometimes within 100 bp. We set out to examine the linkage disequilibrium and diversity in maize elite inbred lines, which have been subject to population bottlenecks and intense selection by breeders. Such population events are expected to increase the amount of linkage disequilibrium, but reduce diversity. The results of this study will inform the design of genetic association studies. |
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