Quantitation of the distribution and flux of myosin-II during cytokinesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Quantitation of the distribution and flux of myosin-II during cytokinesis

Authors:	Douglas?N?Robinson author-information" > author-information__contact u-icon-before" > mailto:Douglas.Robinson@jhu.edu" title=" Douglas.Robinson@jhu.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Guy?Cavet,Hans?M?Warrick,James?A?Spudich

Affiliation:	(1) Departments of Biochemistry and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5307, USA;(2) Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA;(3) Rosetta Inpharmatics, 12040 115th Ave NE, Kirkland, WA 98034, USA

Abstract:	Background During cytokinesis, the cell's equator contracts against the cell's global stiffness. Identifying the biochemical basis for these mechanical parameters is essential for understanding how cells divide. To achieve this goal, the distribution and flux of the cell division machinery must be quantified. Here we report the first quantitative analysis of the distribution and flux of myosin-II, an essential element of the contractile ring.

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