Adh
n5: A temperature-sensitive mutant at the Adh locus in Drosophila |
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Authors: | Charles Vigue William Sofer |
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Institution: | (1) Department of Biology, Johns Hopkins University, Baltimore, Maryland |
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Abstract: | Individuals of an alcohol dehydrogenase-negative strain of Drosophila melanogaster designated Adh
n5 are resistant to ethanol poisoning at low but not at high temperatures. The basis for this behavior is that Adh
n5 flies contain a mutant form of alcohol dehydrogenase which is less heat stable than that of wild-type flies. The mutation in Adh
n5 maps at, or very close to, the presumptive structural locus and is not complemented by any of 11 other alcohol dehydrogenase-null mutants.This research was supported by Grant No. GM 18254 from the National Institutes of Health and Grant No. M55.2217 from the National Cancer Institute.Publication No. 768 from the Department of Biology, Johns Hopkins University. |
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Keywords: | alcohol dehydrogenase Drosophila temperature sensitivity |
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