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Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3 |
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| Authors: | Khalil Hammani Patrick Henriet Scott M Silbiger Yves A Declerck |
| Affiliation: | a Division of Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, CA 90054-0700, USA b Department of Molecular and Cellular Biology, Amgen, Inc., Amgen Center, Thousand Oaks, CA 91320-1789, USA c Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA |
| Abstract: | Using a cDNA probe, two genomic clones were obtained encoding the human tissue inhibitor of metalloproteinases-3 (TIMP-3). Analysis of these clones showed that they contained four distal exons and three introns of the gene. Although the intron-exon structure is similar to that of the timpl gene, the first intron of the timp3 gene is much longer, being at least 17.5 kb in size. |
| Keywords: | Cosmid clone gene structure TIMP-3 intron-exon organization splice sites timp |
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