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Synthesis and evaluation of 4′-5′-dehydro-5′-fluoroaristeromycins as S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitors |
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| Authors: | Siming Liu Michael S. Wolfe Chongsheng Yuan Syed Mashhood Ali Ronald T. Borchardt |
| Affiliation: | Departments of Medicinal Chemistry and Biochemistry, The University of Kansas Lawrence, Kansas 66045 USA |
| Abstract: | 4′,5′-Dehydro-5′-fluoro analogs of aristeromycin were synthesized and shown to be potent inhibitors of recombinant rat liver AdoHcy hydrolase. |
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