Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study |
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| Authors: | Christina L Wassel Fyr Alka M Kanaya Steve R Cummings David Reich Wen-Chi Hsueh Alexander P Reiner Tamara B Harris Susan Moffett Rongling Li Jingzhong Ding Iva Miljkovic-Gacic Elad Ziv |
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| Institution: | (1) Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015, USA;(2) University of California, San Francisco, CA, USA;(3) California Pacific Medical Center, San Francisco, CA, USA;(4) Harvard University, Boston, MA, USA;(5) University of Washington, Seattle, WA, USA;(6) National Institutes of Health, Bethesda, MD, USA;(7) University of Pittsburgh, Pittsburgh, PA, USA;(8) University of Tennessee, Memphis, TN, USA;(9) Wake Forest University, Winston-Salem, NC, USA |
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| Abstract: | Adipocytokines are a subset of cytokines produced by adipose tissue and are associated with risk of type II diabetes and atherosclerosis.
Levels of adipocytokines differ between Black and White Americans, even after adjustment for differences in adiposity, diseases
associated with adipocytokines including type 2 diabetes and cardiovascular disease, and general socioeconomic status indicators
such as income. We used a series of ancestry informative markers to estimate genetic ancestry in a population-based study
of older Black Americans, and examined the association between genetic ancestry and adipocytokines and soluble receptors to
help determine which of these may be most amenable to admixture mapping. We typed 35 ancestry informative markers in 1,241
self-reported Black Americans with available DNA from the Health, Aging, and Body Composition (Health ABC) study with available
DNA and used a maximum likelihood approach to estimate percent European ancestry. We used linear regression models to determine
the association between these adipocytokines and percent ancestry, and staged models to examine whether adiposity or other
measures affected the associations of genetic ancestry and adipocytokines. Mean European ancestry was 22.3 ± 15.9%. In multivariate
adjusted models, the strongest associations observed were between higher European ancestry and interleukin-6 soluble receptor
(IL-6 SR), C-reactive protein (CRP), and adiponectin levels, with interleukin-2 soluble receptor (IL-2 SR) and soluble tumor
necrosis factor receptor II (TNF-α SR II) also showing more modest but significant associations. The association with adiponectin
became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors
influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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