Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine |
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Authors: | Sivapatham Sundaresan Perumal Subramanian |
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Institution: | (1) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India |
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Abstract: | Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation
products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione,
increased activities of glutathione S-transferase, and glutathione peroxidase were observed in liver of NDEA-treated rats when compared with control rats. The
activities of superoxide dismutase and catalase were significantly decreased in tumor tissue when compared with control. Administration
of S-allylcysteine (SAC) showed the inhibition of tumor incidence, modulated the lipid peroxidation, and increased the reduced
glutathione, glutathione-dependent enzymes, superoxide dismutase, and catalase in NDEA-induced carcinogenesis. From our results,
we speculate that S-allylcysteine mediates its chemopreventive effects by modulating lipid peroxidation, GST stimulation, and by increasing the
antioxidants. Hence SAC prevents cells from loss of oxidative capacity in NDEA-induced hepatocarcinogenesis. |
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Keywords: | Antioxidants Hepatocarcinogenesis Lipid peroxidation Nitrosodiethylamine S-allylcysteine |
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