Dendrocyin: an isocucurbitacin with novel cyclic side chain from Dendrosicyos socotrana |
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| Authors: | Hussein Hosny A Abdel-Halim Osama B Marwan El-Sayed M El-Gamal Ali A Mosana Ramazy |
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| Institution: | Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. hosny1953@hotmail.com |
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| Abstract: | Dendrosicyos socotrana Balf.f. is a unique species (Cucurbitaceae) native to Socotra island in the horn of Africa. From the chloroform extract of the stems, A new isocucurbitacin (Dendrocyin) with unusual cyclization in the side chain; 24beta-ethoxy-20-25-epoxy-3alpha,16alpha-dihydroxy-9-methyl-19-norlanost-5(6) ene-2,11,22-trione has been isolated alongside isocucurbitacin R. Their structural configuration were established by usual spectroscopic (1H NMR, 13C NMR and DEPT) and two-dimensional NMR techniques (1H-1H Cosy, HMBC and HMQC). |
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| Keywords: | Dendrosicyos socotrana Balf f Cucurbitaceae Stems Isocucurbitacins |
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