Phenolic acids reduce the genotoxicity of acridine orange and ofloxacin inSalmonella typhimurium |
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Authors: | A Belicová L Križková M Nagy J Krajčovič L Ebringer |
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Institution: | (1) Institute of Cell Biology, Faculty of Science, Comenius University, 811 07 Bratislava, Slovakia;(2) Department of Pharmacognosy and Botany/Faculty of Pharmacy, comenius University, 832 32 Bratislava, Slovakia |
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Abstract: | Naturally occurring plant phenolics,p-coumaric acid (PA), caffeic acid (CA), ferulic acid (FA) and gentisic acid (GA) (25–100 nmol/L) had protective effects on
acridine orange (AO; 216 μmol/L)- and ofloxacin (3 μmol/L)-induced genotoxicity inSalmonella typhimurium. FA, GA and CA exhibited a significant concentration-dependent protective effect against the genotoxicity of AO and ofloxacin,
with the exception of PA, which at all concentrations tested abolished the AO and ofloxacin genotoxicity. UV spectrophotometric
measurements showed the interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction is obviously responsible
for the reduction of AO-inducedS. typhimurium mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and CA is assumed to be a result of their ability
to scavenge reactive oxygen species (ROS) produced by ofloxacin. |
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