Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)). |
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| Authors: | R M Scarborough A M Laibelman L A Clizbe L J Fretto P B Conley E E Reynolds D M Sedlock H Jantzen |
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| Affiliation: | COR Therapeutics, Inc., Departments of Medicinal Chemistry and Biology, 94080, South San Francisco, CA, USA. rscarborough@corr.com |
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| Abstract: | Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists have been discovered that bind reversibly and with high affinity to the platelet receptor. Condensation of various 2-aminobenzothiazoles with chlorosulfonylacetyl chloride affords these novel tricyclic heterocycles, which are novel and unpredicted products of this reaction. |
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