Oncogenes and linkage groups: Conservation during mammalian chromosome evolution |
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| Authors: | Raymond L Stallings A Christine Munk Jonathan L Longmire James H Jett Mark E Wilder Michael J Siciliano Gerald M Adair Brian D Crawford |
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| Institution: | (1) Los Alamos National Laboratory, Genetics and Experimental Pathology Groups, Life Sciences Division, The University of California, 87545 Los Alamos, NM, USA;(2) The University of Texas System Cancer Center, Department of Genetics, M.D. Anderson Hospital and Tumor Institute, 77030 Houston, TX, USA;(3) Science Park Research Division, The University of Texas System Cancer Center, 78957 Smithville, TX, USA |
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| Abstract: | Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS — all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years. |
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