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New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation |
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| Authors: | Frohn Mike Xu Han Zou Xiaoming Chang Catherine McElvaine Michele Plant Matthew H Wong Min Tagari Philip Hungate Randall Bürli Roland W |
| Affiliation: | Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com |
| Abstract: | We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro. |
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