Conformation of a T cell stimulating peptide in aqueous solution |
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Authors: | J P Waltho V A Feher R A Lerner P E Wright |
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Affiliation: | Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037. |
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Abstract: | Using two-dimensional NMR spectroscopy and circular dichroism spectroscopy it is demonstrated that a T cell stimulating peptide corresponding to residues 132-153 of sperm whale myoglobin populates helical conformations in aqueous solution. This finding is in accordance with proposals that immunodominant sites in T cell stimulating peptides have a high conformational propensity. The observation of secondary structure in aqueous solutions of this and other immunogenic peptides has important implications for initiation of protein folding. |
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