1,25-Dihydroxyvitamin D3 inhibits selectively the mitogenic stimulation of mouse medullary thymocytes |
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Authors: | A Ravid R Koren A Novogrodsky U A Liberman |
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Institution: | 1. Rogoff-Wellcome Medical Research Institute, Petah-Tikva, Israel;2. The Unit of Metabolic Diseases, Beilinson Medical Center, Petah-Tikva, Israel;3. Tel-Aviv University, Sackler Medical School, Tel-Aviv, Israel |
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Abstract: | Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physiological concentrations, inhibits the mitogenic response of the medullary cells to phytohemagglutinin and interleukin-2, but has no effect on the cortical subpopulation. Other less active metabolites of vitamin D had little or no effect on medullary cell stimulation. |
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Keywords: | PNA peanut agglutinin PNA-positive cells thymocytes bearing receptors for PNA PNA-negative cells thymocytes lacking receptors for PNA PHA phytohemagglutinin TPA12-O-tetradecanoyl-phorbol-13-acetate IL-1Interleukin-1 IL-2Interleukin-2 |
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