Activation of human ribosomal genes by 5-azacytidine |
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| Authors: | Marina Ferraro Patrizia Lavia |
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| Affiliation: | Institute of Genetics, University of Rome, Rome, 00185 Italy |
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| Abstract: | Cultured human fibroblasts were exposed to 5-azacytidine which inhibits methylation of newly synthesized DNA. A significant increase in the mean number of Ag-stained active nucleolus organizers has been observed in treated cells. This suggests that DNA methylation is involved in modulation of human rRNA synthesis. |
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