Comparison of the Paul ion trap to the linear ion trap for use in global proteomics |
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| Authors: | Riter Leah S Gooding Karen M Hodge Barry D Julian Randall K |
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| Institution: | Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. |
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| Abstract: | A critical evaluation of the performance of a 2-D linear ion trap (IT) instrument to two 3-D quadrupole IT instruments with emphasis on identification of rat serum proteins by bottom-up LC-MS/MS is presented. The speed and sensitivity of each of the instruments were investigated, and the effects that each of these have on the bottom-up proteomics identification approach are discussed. |
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| Keywords: | Linear ion trap Mass spectrometry Protein identification |
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