Evaluation of a serum extender,SERASUP II,for cell growth and production of poliomyelitis viruses by VERO cells |
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| Authors: | S. Rauel E. Wassner M. Reitzer P. Poindron D. Rimmele |
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| Affiliation: | (1) Centre de Recherches Pharmaceutiques, Département d'Immunologie et Immunipharmacologie, Université Louis Pasteur, BP 24, 67401 Illkirch Cedex, France;(2) Institut Jacques BOY S.A., 45, Rue Cognacq Jay, BP 1430, 51065 Reims Cedex, France |
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| Abstract: | Summary A serum extender, SERASUP II, was evaluated for its ability to maintain VERO cell cultures at long term, and for its influence on virus production by cells adapted to that medium. SERASUP II allowed a 90% reduction of the serum amount while maintaining a correct long-term growth. The production of Poliovirus strains 1 and 2 is improved in the extender containing medium, while it is strongly decreased for strain 3. |
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