Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner |
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| Authors: | Burgos Javier S Ramirez Carlos Sastre Isabel Valdivieso Fernando |
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| Affiliation: | NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain
;Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain |
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| Abstract: | There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD. |
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| Keywords: | Alzheimer's disease APOE brain HSV-1 |
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