Focus: Allergic Diseases and Type II Immunity: Study of the Correlation between HRCT Semi-quantitative Scoring,
Concentration of Alveolar Nitric Oxide,and Clinical-functional Parameters of
Systemic Sclerosis-induced Interstitial Lung Disease |
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Authors: | Ha Hoang-Duc Quyen Pham-Huy Thuc Vu-Minh Sy Duong-Quy |
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Affiliation: | aHai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam;bRadiology Department, Hai Phong International Hospital, Hai Phong, Vietnam;cClinical Research Center, Lam Dong Medical College, Dalat, Vietnam;dDivision of Immuno-Allergology, Hershey Medical Center, Penn State Medical College, Hershey, PA, USA |
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Abstract: | Introduction: The correlation between alveolar nitric oxide (CANO) and the severity of interstitial lung disease (ILD) evaluated by high resolution computed tomography (HRCT) has not been well demonstrated. Methods: It was a perspective and observational study, including patients with diagnosed systemic sclerosis (SSc). They performed lung function testing (LFT), exhaled nitric oxide (NO) measurements, exercise testing, chest X-ray, and HRCT. Study patients were divided into SSc with ILD (SSc-ILD+) or without ILD (SSc-ILD-). SSC-ILD+ patients were revisited after 6 months and 12 months to complete the study. Results: Thirty-one control subjects and 74 patients with SSc (33 SSc-ILD- and 41 SSc-ILD+) were included. Forty-one SSc-ILD+ patients were followed-up at 6 months and 12 months. Lung functional parameters of patients with SSc-ILD+ were lower than that of SSc-ILD- patients. The level of CANO was significantly higher in SSc-ILD+ than SSc-ILD- patients (8.6 ± 2.5 vs 4.2 ± 1.3 ppb and P<0.01). Warrick and Goldin scores of patients with SSc-ILD+ were respectively 16.5 ± 5.2 and 12.7 ± 4.3. Warrick scores were reduced after 6 and 12 months of follow-up vs at inclusion (12.4 ± 4.3 and 9.1 ± 3.2 vs 16.5 ± 5.2; P<0.05, P<0.01, and P<0.05; respectively). ΔWarrick and ΔGoldin scores were significantly and inversely correlated with ΔFVC, ΔTLC, ΔTLCO, ΔVO2 max; that was also correlated with ΔCANO (R= 0.783, P<0.01 and R= 0.719 and P<0.05). Conclusion: CANO is a relevant biomarker for the diagnosis of ILD in patients with SSc, especially in combination with HRCT. |
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Keywords: | Systemic sclerosis interstitial lung disease exhaled nitric oxide CANO |
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